The laboratory has 36 staff members, including 1 professor, 2 associate professors, 5 lecturers, 2 post-doctors, 15 doctoral students, and 11 master students. It is a young and energetic research team.
The research direction of the laboratory mainly includes non-coding RNA and osteoporosis, special environmental bone biomechanics MACF1 and bone formation, electromagnetic radiation biology and so on.
The research laboratory has a strong research atmosphere, and holds regular intra-group academic seminars every week. At the same time, it conducts irregular discussions and exchanges on different research directions and specific topics within the group. In addition, members of the laboratory actively participated in academic conferences at home and abroad, including the American Association of Bone Minerals (ASBMR), the International Chinese Association of Osteopathic Research (ICMRS), the Conference on Space Biology, and the Academic Conference of the Society of Cell Biology. Frontiers, open up scientific research horizons, get to know research partners, and promote exchanges and cooperation.
The research institute cooperates with many universities at home and abroad, including the University of Chicago, the University of Rochester Medical Center, the University of Austin, the Hong Kong Baptist University, Xi'an Jiaotong University, and the Northwest A&F University. In addition, the research office has established partnerships with some companies.
The research office undertakes the New Century Excellent Talents Support Program of the Ministry of Education, the National Natural Science Foundation of China, the Youth Project, the China Postdoctoral Special Funding Project, the Surface Project, the Shaanxi Provincial Natural Science Foundation and other scientific research projects, and has published more than 60 papers. Article, applying for more than 10 patents. Based on the tenet of “scientific research and educating people and scientific research people”, the research institute is committed to cultivating outstanding talents and revealing scientific truths. We sincerely hope to cooperate with more domestic and foreign scientific research workers and welcome the intention to engage in bone metabolism. The domestic and foreign students of the study joined the laboratory.
Rearch Direction
Mechanobiology:
From the molecular, cellular, tissue and whole animal level to conduct the mechanism study of mesenchymal stem cells and osteoblast differentiation, load-bearing bone formation and skeletal system related diseases under different mechanical conditions. Choose mechanics sensitive genes (MACF1) and non-coding RNA (microRNA, LncRNA) as breakthrough points to study the molecular mechanism of bone formation while mechanical loading alters.Our research team has established conditional knockout mouse models (fl/fl,Prrx1/+; fl/fl, sp7/+) disrupting MACF1 expression in pre-osteoblasts and mesenchymal stem cells, MACF1 knockin mice through ROSA26 locus and mir-138 transgenicmouse models.
Epigenetic Research on Bone Metabolism Disorders and Nucleic Acid Drug Development:
Focus on osteoporosis, osteoma, osteoarthritis and other bone related disease, evaluate the epigenetic changes of these diseases; screen nucleic acid or small molecule drugs. To be specific, MACF1 was taken as the star molecule, its natural antisense RNA (MACF1AS) was screened; and microRNA/lncRNA that associated with bone metabolism disorder were selected as well to uncover their involvement of bone metabolism diseases; further nucleic acid or small molecule drugs will be developed to prevent and treat metabolic bone diseases.
Human Machine and Environment Engineering:
We devote ourselves to “the impact of special physical environment (electromagnetic radiation, noise, vibration, ultrasound) on the health of special operations personnel”. According to the biological effects, the drugs for preventing and controlling the harm of special physical environment to human will be developed, and the protection for people will be achieved. Our research include: the effects of special physical environment on operators; biological effect assessment of special physical environment and protection policy draft; establish biological safety standards of various electromagnetic radiation physical environment.
Reasearch Topics
1. National Natural Science Foundation of China
1. Qian Airong，“The mechanism of mechanosensitive miR-138-5p inhibits bone formation via regulating MACF1”（31570940）；
2. Qian Airong，“the roles of MACF1 and its NATs in effect of simulated microgravity in migration preosteoblasts”（31370845）；
3. Qian Airong，“the mechanism of microtubule actin crosslinking factor (MACF1) involved in mechanotransduction of osteocyte”.（30970706）；
4. Qian Airong，“The interaction between microtubule-actin crosslinking factor (MACF1) and cytoskeleton in the process of osteoblast sensing gravity”.（30840030）；
5. Qian Airong，“the mechanism of matrix metalloproteinase production induced by Extracellular matrix metalloproteinase inducer”.(30300189）；
6. Li Yu, "Function and Mechanism of CD147 Regulating FOXM1 Ubiquitination Degradation Involved in DNA Damage Resistance of Ovarian Cancer Cisplatin-Resistant Cells" (81872129);
7. HuLifang，“The role of MACF1 in simulated weightlessnessinhibiting osteoblast differentiation through regulating Wnt/β-cateninsignaling”(31400725).
8. HuLifang，“The role and mechanism of MACF1 combined with CDK12 in simulating weightless inhibition of bone formation”(81772017);
9. Lin Xiao, "The mechanism of MACF1/TCF4/miR-335 axis in senile osteoporosis"(81700784);
10. Tian Ye, "MACF1 regulates the anti-oxidation of osteoblasts through the FOXO1/β-catenin pathway and participates in the mechanism of simulated weightless inhibition of bone formation" (81801871);
2. 863 Program
1. National Hightech Research and Development Program of China（863 Program, Key grant, No.2008AA12A220）.
2. National Hightech Research and Development Program of China（863 Program, Key grant, No.2008AA12A218）.
3.Program for New Century Excellent Talents in University of Ministry of Education of China
1. Qian Airong，“the mechanism of gravisensing of bone cells” (NCET-12-0469).
4. Research Foundation of Military
1. Qian Airong, Dang Kai, Key Project of Military Logistics Research Project: Molecular Mechanism of Pilots' Bone Changes. BKJ17J004, 2018-2022.
2. Qian Airong, The 12th Five-Year Key Task of the Military Region: to ensure the development of healthy Chinese medicine products for special environmental groups such as aerospace/plateau/deep sea. BWS12J010-1.
3. Qian Airong, The 12th Five-Year Key Task of the Military Region: To ensure the development of healthy Chinese medicine products for special environmental groups such as aerospace/plateau/deep sea. BWS12J010-1.
4. Qian Airong, The 12th Five-Year Key Task of the Military Region: Qian Xuesen System Science Health Industry Service Project. BWS12J010-3.
5. Qian Airong, Miao Zhiping, Military Commission Science and Technology Commission Innovation Special Zone Project: Battlefield ***THZ Rapid Detection. 18-H863-02-ZT-008-030-01.
5. Natural Science Basic Research Program of Shaanxi
1. Qian Airong, "Natural Science Basic Research Program - Surface Project, Screening and Functional Verification of Microtubule Microfilament Crosslinking Molecular Natural Antisense Transcripts" (2015JM3078)
2. Qian Airong, "Shaanxi Key Research and Development Program - Key Project of International Science and Technology Cooperation Program, Biosynthesis Technology for Recombinant Functional Small RNA" (2018KWZ-10)
3. Hu Lifang, "The role and mechanism of MACF1 involved in simulating pre-osteoblast migration induced by weightlessness" (2015JQ3076)
4. Miao Zhiping, "Key Research and Development Program in Shaanxi Province: Development of Diagnostic Kit for Osteoporosis in Postmenopausal Women" (2018SF-263)
5. Qian Airong, "Shaanxi Province Innovation and Entrepreneurship Dual Tutor System Project: Research and Development of Diagnostic Kit for Senile Osteoporosis" (2018KA180038C180038)
6. Hu Lifang, Young Talent Fund of University Association for Science and Technology in Shaanxi, "The role and mechanism of MACF1 in senile osteoporosis by binding to CDK12" (No. 20170401) 2018.1~2019.12
7. Tian Ye，“General Project of Natural Science Basic Research Program of Shaanxi Province (Youth): "The Mechanism of MACF1 Regulating MAP1B Participation in Bone Formation”（2018JQ8032)
8. Lin Xiao，“Shaanxi Natural Science Foundation Youth Project: "The Role of MACF1/TCF4/miR-335 in Osteogenic Differentiation of MSC"” (2018JQ3049).
6. China Postdoctoral Science Foundational
1. Hu Lifang，"Study on the role of MACF1-induced cytoskeletal rearrangement in weightlessness inhibiting bone formation" (No. 2017M610653), 2017.3~2018.12
2. Hu Lifang，“Studyon the role of MACF1 in simulated weightlessness inhibiting bone formation”(2014M562450)；
3. Hu Lifang，“Therole and mechanism of miR-138-5p in simulated weightlessness inhibiting boneformation”(2015T81051)，postdoctoral special funding.
4. LiXiao, "The regulation of MACF1/miR-335 in MSCs differetiation of osteoporosis"(2017M613196)
5. TianYe, "The role of MACF1 in simulated weightlessness-induced inhibition of osteoblast differentiation through regulating cellular redox balance "(No.2017M613210)
6. Zhang Wenjuan, "Discussion on the material basis and mechanism of action of Huang Qi's heart and brain treatment based on network pharmacology" (2017M623249)
7. Shaanxi Postdoctoral Project
1. Hu Lifang, "The role of MACF1 in regulating cytoskeletal rearrangement in the development of senile osteoporosis";
2. TianYe, "Biosynthesis of recombinant small RNA and its therapeutic effect on weight loss bone loss"
8. Shenzhen Science and Technology Plan Projects
1. Airong Qian,“The Role and Mechanism of MACF1-LncRNA in Senile Osteoporosis”.(JCYJ20160229174320053).
9. Basic Research Foundation of NPU
1. Qian Airong，“The biological effects and its mechanism of simulation gravitational environment on osteoblast”；
2. Qian Airong，“the mechanism of gravisensing of bone cells” (JC201055);
3. Hu Lifang，“Studyon the molecular mechanism of preosteoblast migration to bone formation surface”(3102014JKY15007).
4. Hu Lifang，“A Novel Non-coding RNA Regulates the Molecular Mechanism of MACF1 Involved in Bone Formation”(3102016ZY037).
5. TianYe, "Application of recombinant functional small RNA in the treatment of osteoporosis" (3102018zy053).
10. Other
1. Central University Basic Research Business Funding Project: Zhang Wenjuan, "The material basis and molecular mechanism of jaundice multi-target synergy" (31020170QD050);
2. Central University Basic Research Business Funding Project: Lin Xiao, "Correlation between natural antisense MACF1-AS and bone formation" (3102017QD041);
Scientific research achievements
Publications (*: Corresponding Author):
1. Wenjuan Zhang#, Ying Huai#, Wei Wang, Kaiyue Xue, Lei Chen, Chu Chen*,Airong Qian*. A Retrospective Cohort Study on the RiskFactors of Deep Vein Thrombosis (DVT) for Traumatic Fracture Patients atHonghui Hospital. BMJ Open, 2018 Nov (accepted).
2. WenjuanZhang, Ying Huai, Zhiping Miao, Chu Chen, Mohamed Shahen,Siddiq Ur Rahman, Mahmoud Alagawany, Mohamed E. Abd El-Hack*, Heping Zhao*,Airong Qian*. Systems pharmacology approach to investigate the molecularmechanisms of herb Rhodiola rosea L. radix. Drug Development IndustrialPharmacology, 2018 Nov 17:1-9.
3. Peihong Su, Ye Tian, Chaofei Yang, Xiaoli Ma, Xue Wang, Jiawei Pei, and Airong Qian*. Mesenchmal Stem Cell Migration during Bone Formation and Bone Diseases Therapy.Int. J. Mol. Sci.2018, 19(8), 2343; https://doi.org/10.3390/ijms19082343
4. Yong-Guang Gao, Xiao Lin , Kai Dang, Shan-Feng Jiang, Ye Tian, Fen-Li Liu, Di-Jie Li, Yu Li, Zhi-Ping Miao and Ai-Rong Qian. Structure-activity relationship of novel low generation dendrimers for gene delivery. Organic & Biomolecular Chemistry, 2018, DOI: 10.1039/C8OB01767K
5. Yong-Guang Gao, Uzair Alam, Ai-Xiang Ding, Quan Tang, Zheng-Li Tan, You-Di Shi, Zhong-Lin Lu, Ai-Rong Qian, [12]aneN3-based lipid with naphthalimide moiety for enhanced gene transfection efficiency. Bioorganic Chemistry, 2018, 79, 334-340.
6. Hu L, Yin C, Zhao F, Ali A, Ma J, Qian A*. Mesenchymal StemCells: Cell Fate Decision to Osteoblast or Adipocyte and Application in Osteoporosis Treatment. Int J Mol Sci. 2018 Jan 25;19(2)
7. Li S, Miao Z, Tian Y, Wang H, Wang S, He T, Yang Y, Wang P,Ma M, Yang T, Qian A* and Chen C*. Limethason reduces airway inflammation in a murine model ofovalbumin-induced chronic asthma without causing side effects. Experimental and Therapeutic Medicine. January 4, 2018
8. Zhang Y, Yin C, Hu L, Chen Z, Zhao F, Li D, Ma J, Ma X, Su P,Qiu W, Yang C, Wang P, Li S, Zhang G, Wang L, Qian A*, Xian C. MACF1Overexpression by Transfecting the 21-kbp Large Plasmid PEGFP-C1A-ACF7 PromotesOsteoblast Differentiation and Bone Formation. Hum Gene Ther. 2018 Jan 15
9. Yin C1,2,3, Zhang Y1,2,3, Hu L1,2,3, Tian Y1,2,3, Chen Z1,2,3, Li D1,2,3, Zhao F1,2,3, Su P1,2,3, MaX1,2, Zhang G2,3, Miao Z1,2,3, Wang L4, Qian A1,2,3, Xian CJ4. Mechanical unloading reducesmicrotubule actin crosslinking factor 1 expression to inhibit beta-cateninsignaling and osteoblast proliferation. J Cell Physiol. 2017 Dec 8.
10. Qian A1,Hu L2. Spectraplakins, versatile roles in physiologyand pathology. Semin Cell Dev Biol. 2017 Sep; 69:1-2.
11. Miao Z, Ali A, Hu L, Zhao F, Yin C, Chen C, Yang T, Qian A*. Microtubule actin cross-linking factor 1, a novel potential target in cancer. Cancer Sci. 2017 Oct;108(10):1953-8.
12. Zhihao Chen, Yan Zhang, Chao Liang, Lei Chen, Ge Zhang* and Airong Qian*; Mechanosensitive miRNAs and Bone Formation. Int .J .Mol. Sci. 2017, 18(8), 1684.
13. Ali A1, Hu L1, Zhao F1, Qiu W1, Wang P1, Ma X1, Zhang Y1, Chen L1, Qian A2.BPAG1, a distinctive role in skin and neurological diseases.Semin Cell Dev Biol. 2017 Jun 13.doi:10.1016/j.semcdb.2017.06.005
14. Hu L1,2,3, Su P1,2,3, Yin C1,2,3, Zhang Y1,2,3, Li R1,2,3, Yan K1,2,3, Chen Z1,2,3, Li D1,2,3, Zhang G2,3, Wang L4, Miao Z1,2,3, Qian A1,2,3, Xian CJ4.Microtubule actin crosslinking factor 1 promotes osteoblast differentiation by promoting β-catenin/TCF1/Runx2 signaling axis.J Cell Physiol. 2017 Jun 16. doi: 10.1002/jcp.26059.
15. Hu L1, Xiao Y1, Xiong Z1, Zhao F1, Yin C1, Zhang Y1, Su P1, Li D1, Chen Z1, Ma X1, Zhang G2, Qian A3. MACF1,versatility in tissue-specific function and in human disease.Semin Cell Dev Biol. 2017 May 31. pii: S1084-9521(16)30321-4. doi: 10.1016/j.semcdb.2017.05.017.
16. MIAO Zhi-ping,QIU Wu-xia,MA Xiao-li,QIAN Ai-rong. Advances in Ｒesearch on Effects of Space Microgravity on Bone Metabolism. Journal of Astronautics.DOI: 10.3873/j.issn.1000-1328.2017. 03.001
17. Miao Zhiping,Yin Chong,Zhang Yan,Hu Li-fang,Li Dijie,Chen Zhihao,Qian Airong. Effects of Simulated Weightlessness with Ｒandom Positioning Machine on Microtubule Actin Crosslinking Factor 1 Expression and β-catenin Pathway in Osteoblast. Space Medicine ＆ Medical Engineering. 2017,30(1): 7-11
18. Hu L1, Su P1, Li R1, Yin C1, Zhang Y1, Shang P1, Yang T2, Qian A1.Isoforms, structures, and functions of versatile spectraplakin MACF1.BMB Rep. 2016 Jan;49(1):37-44. doi: 10.5483/BMBRep.2016.49.1.185.
19. Kun Yan,Yasir Arfat,Dijie Li,Fan Zhao,Zhihao Chen,Chong Yin,Yulong Sun,Lifang Hu,Tuanmin Yang* & Airong Qian*.Structure Prediction:New Insights into Decrypting Long Noncoding RNAs. Int.J.Mol.Sci.2016,17(1),132 .
20. Zhihao Chena, Fan Zhaoa, Yiduo Qia, Lifang Hua, Dijie Lia, Chong Yina, Peihong Sua, Yan Zhanga,
Jianhua Maa,b, Jing Qiana, Hongpo Zhoua, Yiwei Zoua, Airong Qiana*, Simulated microgravity alters the expression of cytoskeleton- and ATP binding-related genes in MLO-Y4 osteocytes.Acta Astronautica 129 (2016) 186–192.
21. Li Dijie1，Chen Zhihao1，Liu Zonglin1，Lin Yu1，Ding Chong1，Zhao Fan1，Arfat Yasir1，Hu Lifang1，Li Yongzhi2* ，Shang Peng1* ，Qian Airong1*.Qiang Gu Kang Wei Prescription Increases Bone Mineral Density of Load-bearing Bone in Tail Suspended Rats.Space Medicine & Medical Engineering.2016, 29(1)
22. Lifang Hu, Peihong Su, Runzhi Li, Kun Yan, Zhihao Chen, Peng Shang & Airong Qian*. Knockdown of microtubule actin crosslinking factor 1 inhibits cell proliferation in MC3T3-E1 osteoblastic cells. BMB Rep. 2015, 48(10):583-8.
23. Lifang Hu, Peihong Su, Runzhi Li, Chong Yin, Yan Zhang, Peng Shang, Tuanmin Yang& Airong Qian*. MACF1, a versatile spectraplakin: isoforms, unique structures, and functions. BMB Rep. 2015 Nov 2. pii: 3336.
24. Yang Wang, ZhiHao Chen, Chun Yin, JianHua Ma, DiJie Li, Fan Zhao, YuLong Sun, LiFangHu, Peng Shang*, AiRong Qian*.GeneChip Expression Profiling Reveals the Alterations of Energy MetabolismRelated Genes in Osteocytes under Large Gradient High Magnetic Fields.PLoS One. 2015, 10 (1): e0116359.
25. Yasir Arfat,WeiZhong Xiao, Munazza Ahmad, Fan Zhao, Di-Jie Li, Yu-Long Sun, Li-Fang Hu,ZhiHao Chen, Ge Zhang, Peng Shang, AiRong Qian*. Role of microRNAs in osteoblasts differentiation and bone disorders.Current Medicinal Chemistry. 2015, 22 (6):748-58.
26. YuLong Sun, Xiao-Hu Chen, ZhiHao Chen, Xiao-Li Ma,DiJie Li, Peng Shang, AiRong Qian*.Neuropeptide FF attenuates RANKL-induced differentiation of RAW264.7 cells intoosteoclast-like cells. Archives of Oral Biology. 2015, 60,282-292.
27. YuLong Sun, Zhi-Hao Chen, XiaoHu Chen, Chong Yin,DiJie Li, Xiao-Li Ma, Fan Zhao, Ge Zhang, Peng Shang*, AiRong Qian*. Diamagnetic levitation promotes osteoclast differentiation from RAW264.7 cells. IEEE Transactions on Biomedical Engineering.2015, 62(3): 900-8.
28. Chao Liang, Baosheng Guo,Heng Wu, NingSheng Shao, DeFang Li, Jin Liu, Lei Dang, Cheng Wang, Hui Li,Shao-Hua Li, Wing Ki Lau, Yu Cao, ZhiJun Yang, Cheng Lu, XiaoJuan He, D W TAu, XiaoHua Pan, BaoTing Zhang, ChangWei Lu, HongQi Zhang, KinMan Yue, AiRong Qian, Peng Shang, JiaKe Xu,LianBo Xiao, ZhaoXiang Bian, WeiHong Tan, ZiCai Liang, FuChu He,LingQiang Zhang*, AiPing Lu* & Ge Zhang*. Aptamer-functionalized lipidnanoparticles targeting osteoblasts as a novel RNA interference-based boneanabolic strategy. Nature Medicine. 2015, 21(3): 288-94.
29. Jin Liu, LeiDang, DeFang Li, Chao Liang, XiaoJuan He, Heng Wu, AiRong Qian, ZhiJun Yang, Au, Doris W.T. Chiang, Michael W.L.,BaoTing Zhang, QuanBin Han, Yue, Kevin K.M. ; HongQi Zhang, ChangWei Lv,XiaoHua Pan, JiaKe Xu, ZhaoXiang Bian, Peng Shang, WeiHong Tan, ZiCai Liang, BaoSheng Guo, AiPing Lu, Ge Zhang. A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation ofmicroRNAs in osteoclasts. Biomaterials. 2015, 52:148-160.
30. Yasir Arfat, Nasir Mahmood, Muhammad Usman Tahir,Maryam Rashid,Sameer Anjum, Fan Zhao, DiJie Li, YuLong Sun, Li-fang Hu,Zhihao Chen, Chong Yin, Peng Shang, AiRongQian*. Effect of imidacloprid on hepatotoxicity and nephrotoxicityin malealbino mice. Toxicology Reports, 2014, 1:554–561
31. Yasir Arfat*, Nasir Mahmood, Munazza Ahmad, Muhammad Tayyab, Fan Zhao, DiJie Li, ZhiHao Chen, Chong Yin, Peng Shang, AiRong Qian. Effect of date palmpollen on serum testosterone and intra-testicular environment in male albinorats. Journal of Pharmacy and Pharmacology, 2014, 8(31):793-800.
32. Yasir Arfat,WeiZhong Xiao, Salman Iftikhar, Fan Zhao, DiJie Li, YuLong Sun, Ge Zhang,Peng Shang, AiRong Qian*.Physiological effects of microgravity on bone cells. Calcified Tissue Internationaland Musculoskeletal Research. 2014, 94: 569-579
33. YuLong Sun,Zhi-Hao Chen, XiaoLi Ma, DiJie Li, Fan Zhao, Peng Shang, TuanMing Yang*, AiRong Qian*. NeuropeptideFF inhibits LPS-mediated osteoclast differentiation of RAW264.7 cells. Protein& Peptide Letters. 2014, 22 (3):270-84.
34. LiFang Hu, RunZhi Li,PeiHong Su, Peng Shang, AiRong Qian*. Response and Adaptation of Bone Cells to Simulated Microgravity. Acta Astronautica.2014, 104 (1): 396-408.
35. Fan Zhao, DiJie Li, Yasir Arfat, Zhihao Chen ,Zong-Lin Liu, Yu Lin, Chong Ding, YuLong Sun, LiFang Hu, Peng Shang. AiRong Qian*. Reloading partly recovers bone mineral density and mechanical properties in hind limb unloadedrats. Acta Astronautica. 2014,105 (1): 57-65.
36. AiRong Qian, Xiang Gao, Wei Zhang, JingBao Li, Yang Wang,ShengMeng Di, LiFang Hu, Peng Shang* Large Gradient High Magnetic Fields Affect Osteoblast Ultrastructure and Function by Disrupting Collagen I orFibronectin / αβ1 Integrin.PLoS One. 2013, 8 (1): e51036.
37. Ai-Rong Qian; DaChuan Yin, Peng-Fei Yang, Yi Lv, ZongChengTian, Peng Shang*. Application of diamagnetic levitation technology inbiological sciences research. IEEE Transactions on AppliedSuperconductivity, 2013, 23 (1): 3600305.
38. AiRong Qian, Lei Wang, Xiang Gao, Wei Zhang, LiFang Hu, JingHan, JingBao Li, ShengMeng Di, Peng Shang*.Diamagnetic levitation causes changes in the morphology, cytoskeleton and focal adhesion proteins in osteocytes. IEEE Transactions on Biomedical Engineering. 2012, 59 (1): 68-77.
39. AiRong Qian, DongLi, Jing Han, Xiang Gao, ShengMeng Di, Wei Zhang, LiFang Hu, Peng Shang*.Fractal dimension as a measure of altered actin cytoskeleton in MC3T3-E1 cells under simulated microgravity using 3-D/2-D clinostats. IEEE Transactions on Biomedical Engineering. 2012, 59 (5): 1374- 1380.
40. AiRong Qian, J.-P. Jin*.H2-Calponin Dynamics and Function in Cytokinesis.Biophysical Journal.2012, 102 (3): 373a.
41. AiRong Qian, PengFei Yang, LiFang Hu, Wei Zhang, ShengMeng Di, Zhe Wang, Xiang Gao,Li Xie, YinYin Weng, JianPin Cao, Peng Shang*. High magnetic gradient environment causes alterations of cytoskeleton and cytoskeleton associated genes in human osteoblasts cultured in vitro. Advances in Space Research, 2010,46: 687-700.
42. ZongLin Liu, AiRongQian*, Peng Shang. MACF1 and cytoskeleton. Chinese Journal of Cellular andMolecular. 2012，28 (2): 209-211.
43. Yu Lin, AiRong Qian*, ZongLin Liu, PengShang. A mice hindlimb unloading (HLU) model to simulate microgravity. SpaceMedicine & Medical Engineering. 2012, 25 (4): 239-242.
44. Wang Yang, AiRong Qian*, Peng Shang. The roles of stanniocalcin in bone metabolism in mammal.Chinese Journal of Cell Biology. 2014(4):343-348.
45. AiRong Qian, PengFei Yang, LiFang Hu, Wei Zhang, ShengMeng Di, Zhe Wang, Xiang Gao, Li Xie, YinYin Weng, JianPin Cao, Peng Shang*. High magnetic gradient environment causes alterations of cytoskeleton and cytoskeleton associated genes in human osteoblasts cultured in vitro.Advances in Space Research, 2010, 46: 687-700.
46. Books：
47. AirongQian. Antibody Fusion Protein , see Beifen Shen,Zhinan Chen, Minpei Liu ,Ed in Chief, Recombinant Antibodies, 2005,Scientific Press.
48. Patents：
49. Fang Ye, Jin Xie, Meifang He, Airong Qian, Honglong Chong. Cell positioning culture chip based on single cell capture and use and preparation method thereof. CN-106047706-B.
50. Airong Qian, Lifang Hu, Pai Wang, Xiaoli Ma, Fan Zhao, Wuxia Qiu, Ru Zhang, Lei Chen, Chong Yin, Zhihao Chen, Peihong Su, Dijie Li, Yan Zhang, Chaofei Yang, Siyu Li. Construction method of MACF1 fixed-point transgenic mouse model. 201710672223.6
51. Airong Qian,Lifang Hu,Wuxia Qiu,Xiaoli Ma,Fan Zhao,Ru Zhang,Pai Wang,Lei Chen，Chong Yin,Zhihao Chen,Peihong Su,Dijie Li,Yan Zhang,Siyu Li,Chaofei Yang.Construction and Application of Mice Model with MACF1 Conditional Knockout in Osteoblasts.201710280283.3
52. Airong Qian,Chong Yin,Zhiping Miao,Yan Zhang,Lifang Hu,Zhihao Chen,Fan Zhao,Dijie Li,Jianhua Ma,Peihong Su,Xiaoli Ma,Wuxia Qiu,Chaofei Yang,Siyu Li,Pai Wang.Application of Lnc-DIF.201710036464.1
53. Airong Qian,Lifang Hu,Jianhua Ma,Siyu Li,Fan Zhao,Zhihao Chen,Dijie Li, Chu Chen,Tuanmin Yang,Chong Yin,Peihong Su,Xiaoli Ma,Yan Zhang,Wuxia Qiu,Ru Zhang,Pai Wang,Chaofei Yang.Serum microRNA diagnostic markers and diagnostic kits for Aged osteoporosis fracture.CN106591487A
54. Airong Qian,Xiaoli Ma,Lifang Hu,Fan Zhao,Ru Zhang,Wuxia Qiu,Pai Wang,Peihong Su,,Zhihao Chen,Dijie Li,Chong Yin,Zhiping Miao,Lei Chen. Construction and application of a conditional knockout mouse model of MACF1 gene in mesenchymal stem cells. 201710008830.2
55. Airong Qian,Jianhua Ma,Fan Zhao,Zhihao Chen,Lifang Hu,Dijie Li,Chong Yin,Xiaoli Ma,Peihong Su. Application of Oligonucleotide Compounds Associated With microRNA in Senile Osteoporosis. 201610555353.7
56. Airong Qian,Lifang Hu,Chong Yin,Fan Zhao,Zhihao Chen,Yan Zhang,Jianhua Ma,Peihong Su,Dijie Li,Wuxia Qiu,Xiaoli Ma,Pai Wang. Application of MACF1 Gene and Its Expression Product in Producing Drug for Osteoporosis Diagnosed and Treated. 201610530383.2
57. Airong Qian,Lifang Hu,Chong Yin,Yan Zhang,Jianhua Ma,Fan Zhao,Zhihao Chen,Dijie Li,siyu Li,Xiaoli Ma,Wuxia Qiu,Chaofei Yang,Pai Wang,Peihong Su. Application of miR-489-3p in Producing Drug for Osteoporosis Diagnosed and Treated. CN106011264A
58. Airong Qian,Zhihao Chen, Yasir Arfst,Chong Yin,Lifang Hu,Fan Zhao,Dijie Li,Ya Zhang,Ruizhi Li,Peihong Su,Xiaoli Ma,Wuxia Qiu.Mechanical sensitivity of miR - 138-5 p as drugtargets applied in the musculoskeletal system disease. Patent Number: CN105169411A;
59. Airong Qian,Peng Shang,Lifang Hu,Ruizhi Li,Peihong Su,Chong Yin,Kun Yan,Zhihao Chen,Yiduo Qi,Yulong Sun.An effective inhibit mice MACF1 shRNA screeningand application of gene expression.Patent Number: CN104531700A;
60. Zhinan Chen,Baocheng Huang,Peng Shang,Airong Qian,Ping Zhu.HAb18G/CD147, its antagonist and application. Patent Number:ZL01131735.3;
61. Peng Shang,Dachuan Yin,Airong Qian,Chaohua Shi,Xiaoping Xue,Zengxiang Fu,Bin Jia,Zongcheng Tian,Xuchu Zheng,Wei Zhang.Experimental facility for space gravitational biologyin the high gradient magnetic field. Patent Number: 101188069；
62. Peng Shang,JingbaoLi,Gang He,Liang Wang,Airong Qian.The method for determination of protein concentration in solution by using glutaraldehyde induced infrared fluorescence.Patent Number: CN101846625A；
63. JingbaoLi,Peng Shang,Yanan Li，Airong Qian.The method and apparatus for filtering and counting stained cells.Patent Number: ZL 201120119330.4；
64. JingbaoLi,Peng Shang,Meng Wang，Jia Wang，Yanan Li,Airong Qian.A method for evaluating cell wall off strength using cell wall removal reagent. Patent Number: ZL201210199358.2.
65. Meetings:
66. Airong Qian*, Zhihao Chen, Yasir Arfat, Lifang Hu, Peng Shang, Ge Zhang. Mechanical unloading sensitive miR-138 targets MACF1 to regulate bone formation. 2015 American Society for Bone and Mineral Research (ASBMR), Seattle, USA, 2015, Oct. 9-12.
67. Airong Qian*, Lifang Hu, Yulong Sun, Zhihao Chen, Yasir Arfat, Dijie Li, Chong Yin, Peihong Su, Runzhi Li, Kun Yan, Peng Shang, Ge Zhang. The Response of MACF1 to Simulated Microgravity and Its Noncoding RNAs in Regulating Osteogenesis. 6th China-Germany Workshop on Microgravity and Space Life Sciences Hangzhou, China. 2015.Sept.25-28
68. Airong Qian*, Lifang Hu, Yulong Sun, Zhihao Chen, Yasir Arfat, Dijie Li, Chong Yin, Peihong Su, Runzhi Li, Kun Yan, Peng Shang, Ge Zhang. The role of MACF1 and its noncoding RNA in osteogenesis. The International Chinese Musculoskeletal Research Society (ICMRS) Conference and Xiangya Osteoporosis Forum, Changsha, China. 2015, April 9-11.
69. AiRong Qian*, Li-Fang Hu, YuLong Sun, DiJie Li, Zhi-Hao Chen, Peng Shang, Ge Zhang. The role of MACF1 inmigration, proliferation and differentiation of Osteoblast and the screening ofthe natural antisense transcripts of MACF1. 2014 American Society for Boneand Mineral Research (ASBMR), Houston, USA. 2014, Sept. 12-15. (ISTP)
70. AiRong Qian*, LiFang Hu, Yang Wang, Peng Shang. Response and Adaption of Bone Cells to Mechanical Stimulation. 2013 American Society for Bone and Mineral Research (ASBMR),Boltimore, USA. 2013, Oct. 4-7. (ISTP)
71. AiRong Qian*, Xiang Gao, Wei Zhang, Lifang Hu, Peng Shang, JianPing Jin. Diamagneic levitation changes morphology,cytoskeleton architecture and h2-calponin expression in bone cells. BiophysicalSociety 55th Annual Meeting. Baltimore, Maryland,Mar5-9,2011.
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