The Biomaterials and Pharmaceutical Technology Laboratory is an integral part of the National Defense Key Discipline Laboratory for Space Biological Experiment Simulation Technology，which belongs to Northwestern Polytechnical University School of Life. At present, there are 17 staff members in the laboratory, including 2 professors, 2 associate professors, 3 lecturers, 5 doctoral students and 12 master students. The research office undertakes a number of scientific research projects including the National Natural Science Foundation, the National 973 Subproject, the National Postdoctoral Fund, and the Basic Research Fund of the Central University of Northwestern Polytechnical University.
Research direction
1. Biomaterials: A. Biofunctional materials; B. Biomaterial surfaces; C. Biomanufacturing and bionics
2. Drug technology: A. Drug molecular design and activity screening; B. Targeted slow-release drug preparation; C. Special medicine
Team member
Research project
1. National Natural Science Foundation of China Youth Science Fund Project (81803491): Construction of dual probe co-loaded tumor permeability nano fluorescence detection system and its application in breast cancer PDT precision therapy,2019.1-2021.12
2. National Natural Science Foundation of China Youth Science Fund Project (51801158): Design of double-diameter TiO2 nanotube layer on porous titanium surface and its dual drug controlled release antibacterial and osseointegration, 2019. 1-2021.12
3. Shaanxi Provincial Natural Science Basic Research Program (2019JQ-320): Application of tumor permeability nano-detection system in PDT precision treatment of triple-negative breast cancer, 2019.1-2020.12
4. Basic Research Program of Natural Science of Shaanxi Province (2018JQ8018): pH-responsive controlled-release antibacterial behavior and osseointegration mechanism of barium titanate nanotube-loaded LL37, 2018.1-2019.12
5. Shaanxi Provincial Natural Science Basic Research Program (2018JQ3071), the construction of a novel polypeptide-based scaffold and the mechanism of promoting bone regeneration under three-dimensional rotational culture, 2018.1-2019.12
6. China Postdoctoral Science Foundation Project (2018M633584): A Guideline for Tumor Permeability Nano-Detection System for Breast Cancer PDT Therapy, 2011.5-2020.4
7. China Postdoctoral Science Foundation Project (W016343): Controlled Release Antibacterial Behavior and Osteointegration of TiO2 Nanotube Loaded Active Elements and Peptides, 2018.1-2019.12
8. China Postdoctoral Science Foundation Project (W016342): Effects of three-dimensional culture under simulated microgravity on stem cell proliferation and osteogenic differentiation, 2018.01-2019.12
9. Shaanxi Postdoctoral Research Funding Project (2018BSHQYXMZZ43): Construction of Targeted EGFR Intelligent Nano-Diagnostic System and Its Application in TNBC Precision Therapy, 2018.11-2020.11
10. Shaanxi Natural Science Foundation Project (2018JM4043): Rapid Repair and Regeneration Skin Technology, 2018.1-2019.12
11. Shaanxi Provincial Development and Reform Commission High-level University Construction Special Fund Project—Bio-Innovation Platform Project (0500-17SF0002), 2011.5-2018.4
12. Central University Fundamental Research Fund Project (3102017OQD051): TiO2 Nanotube Coating Construction and Osteointegration on Porous Titanium Surface, 2017.1-2018.12
13. Central University Fundamental Research Fund Project (31020170QD046): Study on the mechanism of action of new polyurethane/polyurea scaffolds and MC3T3-E1 cells in three-dimensional rotary culture, 2017.1-2018.12
14. Research Funding for Fundamental Scientific Research Business Fees of Central Universities (3102015ZY085): Chemotactic Factor-Modified Scaffold Materials In-Situ Recruitment of Autologous Stem Cells and Macrophage Response, 2015.1-2016.12
15. Natural Science Foundation of Shaanxi Province (2015JM2067): Synthesis of riluzole derivatives and its analgesic mechanism, 2015.1-2016.12
16. Shaanxi Provincial Natural Science Basic Research Program (2015JM5177): Research on PLGA-based nanofiber materials loaded with growth factors, 2015.1-2016.12
17. Funded by the special fund for basic scientific research in central colleges and universities (3102014JKY15005): Synthesis of riluzole derivatives and study on the mechanism of analgesic action, 2014.5-2016.5
18. National Natural Science Foundation of China (21202130): Design and Synthesis of Fluorescent Probes for Labeling Sugars and Their Tracer Oligosaccharide Absorption Mechanisms, 2013.1-2015.12
19. National 973 Project (2012CB619101): Functional Design and Biocompatibility Mechanism of Metal Implant Materials, 2012.1-2016.12
20. National Natural Science Foundation of China Youth Fund Project (51103116): Correlation and molecular mechanism of compatibility and solubilization of polymer micelles with drugs, 2012.1-2014.12
21. Natural Science Foundation of Shaanxi Province (2010JM2021): Design, Synthesis and Properties of Positive Charge Phospholipid Polymers, 2010.6-2012.12
22. National Science and Technology Major Special Major Drug Creation (2009ZX09103-113): MAP-5-FU Colon Cancer Double Targeting Drug Research, 2009.9-2012.8
23. National Natural Science Foundation of China (20872119): Synthesis of lipophilic bisphosphonates and their activity on bone loss caused by weight loss, 2009.1-2011.12
24. Central University Fundamental Research Fund (WO18104): Design and Synthesis of Lipophilic Diphosphonates against Space Bone Loss, 2008.1-2010.12
Research results
Double fluorescent smart bandage Ultra-fast dissolving hydrogel dressing
Nano glue Tough tissue adhesive
Multifunctional hemostatic sponge expansion and compression hemostasis (left) and penetrating injury to stop bleeding (right)
Flexible electrode
pH-responsive micelles induce apoptosis by amplifying tumor
cell reactive oxygen species
pH sensitive hydrogel
Double-tube nanotube coating on porous titanium surface and its
pH-responsive drug release
Biological effects of bone implant materials
Published papers
1. H Qi, S Heise, J Zhou, K Schuhladen, Y Yang, S Yang, N Cui, R Dong, S Virtanen, Q Chen, A R Boccaccini, T Lu*. Electrophoretic deposition of bioadaptive drug delivery coatings on magnesium alloy for bone repair, ACS Appl Mater. Interfaces, 2019, 8: 8625-8634.
2. Cui Ning, Jing Jiajia, Li Meng, Qi Hongfei, Wu Xianglong, Lu Tingli*. Electrophoretic deposition of GHK-Cu loaded MSN-chitosan coatings with pH-responsive release of copper and its bioactivity. Materials Science and Engineering: C, 2019, accepted.
3. S Heise, C Forster, S Heer, H Qi, J Zhou, S Virtanen, T Lu*, A R. Boccaccini*. Electrophoretic deposition of gelatine nanoparticle/chitosan coatings. Electrochimica Acta, 2019, 307: 318-325.
4. Dong K, Lei Q, Qi H, Zhang Y, Cui N, Wu X, Xie L, Yan X, Lu T*. Amplification of oxidative stress in MCF-7 cells by a novel pH-responsive amphiphilic micellar system enhances anticancer therapy. Molecular pharmaceutics, 2019, 16(2): 689-700.
5. Li M, Chen Q, Ma M, Liu X, Dong K, Zhang Y, Lu T*. Electrophoretic deposition of core-shell Ag@MSN incorporated-chitosan coatings with biocompatible and antibacterial activities. Materials Letters, 2019, 239: 29-32.
6. Q Chen, J Jing, H Qi, I Ahmed, H Yang, X Liu,T Lu*, A R Boccaccini*. Electric field-assisted orientation of short phosphate glass fibers on stainless steel for biomedical applications. ACS Appl. Mater. Interfaces, 2018,10(14): 11529-11538.
7. Kai Dong, Chunrong Yang, Yan Yan, Pengchong Wang, Ying Sun, Ke Wang, Tingli Lu, Qiang Chen, Yanni Zhang, Jianfeng Xing*, Yalin Dong*. Investigation of the intracellular oxidative stress amplification, safety and anti-tumor effect of a kind of novel redox-responsive micelle. Journal of Materials Chemistry B, 2018, 6(7): 1105-1117.
8. Yanni Zhang, Ying Chen, Hongchao Kou, Pengfei Yang, Yanen Wang, Tingli Lu, Enhanced bone healing in porous Ti implanted rabbit combining bioactive modification and mechanical stimulation, Journal of the Mechanical Behavior of Biomedical Materials, 2018, 86: 336-344.
9. H Qi, Q Chen, H Ren, X Wu, X Liu, T Lu*, Electrophoretic deposition of dexamethasone-loaded gelatin nanospheres/chitosan coating and its dual function in anti-inflammation and osteogenesis. Colloids and Surfaces B: Biointerfaces, 2018, 169: 249-256.
10. Y Zhang, Y Chen, H Kou, P Yang, Y Wang, T Lu*. Enhanced bone healing in porous Ti implanted rabbit combining bioactive modification and mechanical stimulation. Journal of the Mechanical Behavior of Biomedical Materials, 2018, 86:336-344.
11. Wu X, Liu L, Li Y, Luo J, Gai D, Lu T*, Mei Q*. Synthesis, crystal structure, and antinociceptive effects of some new riluzole derivatives. Medicinal Chemistry Research, 2018, 27(5): 1374-1383.
12. Ning Cui, Junmin Qian, Jinlei Wang, Chuanlei Ji, Weijun Xu, Hongjie Wang, Preparation, Physicochemical Properties and Biocompatibility of PBLG/PLGA/Bioglass Composite Scaffolds，Materials Science and Engineering: C,2017,71:118-124.
13. Wang Y, Wang K, Li X, Wei Q, Chai W, Wang S, Che Y, Lu T*, Zhang B*. 3D fabrication and characterization of phosphoric acid scaffold with a HA/beta-TCP weight ratio of 60: 40 for bone tissue engineering applications, PLoS ONE, 2017, 12(4): 1-14.
14. Zhang Yanni#, Zhang Lan, Li Bo, Han Yong*, Enhancement in sustained release of antimicrobial peptide from dual-diameter structured TiO2 nanotubes for long-lasting antibacteria and cytocompatibility, ACS Applied Materials & Interface, 2017, 9: 9449-9461.
15. Zhang Yanni#, Han Yong*, Zhang Lan, Formation and bioactivity of SrTiO3 nanotubes on titanium by modified anodization and hydrothermal treatment, Journal of Materials Science & Technology, 2016, 32: 930-936.
16. H Qi, Z Ye, H Ren, N Chen, Q Zeng, X Wu, T Lu*. Bioactivity assessment of PLLA/PCL/HAP electrospun nanofibrous scaffolds for bone tissue engineering. Life Sciences, 2016, 148: 139-144.
17. Ning Cui, Junmin Qian, Weijun Xu, Minghui Xu, Na Zhao, Ting Liu, Hongjie Wang, Preparation, Characterization, and Biocompatibility Evaluation of Poly(N-acryloyl-l-lysine)/Hyaluronic Acid Interpenetrating Network Hydrogels, Carbohydrate Polymers,2016,136:1017-1026.
18. Chen, Qiang, Li, Wei, Yao, Qingqing, Liang, Ruifang, Pérez-Garcia Rosalina, Munoz, Josemari, Boccaccini Aldo R.. Multilayered drug delivery coatings composed of daidzein-loaded PHBV microspheres embedded in a biodegradable polymer matrix by electrophoretic deposition. Journal of Materials Chemistry B. 4(29): 5035-5045. 2016.
19. Ning Cui, Junmin Qian, Jinlei Wang, Yaping Wang, Weijun Xu, Hongjie Wang, Physicochemical Properties and Biocompatibility of PZL/PLGA/Bioglass Composite Scaffolds for Bone Tissue Engineering, RSC Advances,2016, 6:97096-97106.
20. Ning Cui, Junmin Qian, Jinlei Wang, Chuanlei Ji, Weijun Xu, Hongjie Wang, Preparation and Characterization of Foamy Poly(γ-benzyl-L-glutamate-co-L-phenylalanine)/Bioglass Composite Scaffolds for Bone Tissue Engineering, RSC Advances,2016,6:73699-73708.
21. Song Jiankang, Chen Qiang, Zhang Yang, Mani Diba, Eva Kolwijck, Shao Jinlong, John A. Jansen, Fang Yang, Aldo R. Boccaccini, Sander C. G. Leeuwenburgh. Electrophoretic deposition of chitosan coatings modified with gelatin nanospheres to tune the release of antibiotics. ACS applied materials & interfaces, 2016, 822: 13785-13792.
22. Wen Zhao, Jiaojiao Li, Kaixiang Jin, Wenlong Liu, Xuefeng Qiu, Chenrui Li, Fabrication of functional PLGA-based electrospun scaffolds and their applications in biomedical engineering. Materials Science & Engineering C, 2016, 59:1181-1194.
23. Qi Hongfei, Ye Zhihong, Ren Hailong, Chen Nana, Zeng Qingyan, Wu Xianglong,Lu Tingli. Bioactivity assessment of PLLA/PCL/HAP electrospun nanofibrous scaffolds for bone tissue engineering. Life sciences, 2016, 148: 139-144.
24. Dong K, Yan Y, Wang PC, Shi XP, Zhang L, Wang K, Xing JF, Dong YL. Biodegradable mixed MPEG-SS-2SA/TPGS micelles for triggered intracellular release of paclitaxel and reversing multidrug resistance. International Journal of Nanomedicine. 2016, 11: 5109-5123.
25. Dong K, Zhang HF, Yan Y, Sun JY, Dong YL, Wang K, Zhang L, Shi XP, Xing JF. Improvement of side-effects and treatment on the experimental colitis in mice of a resin microcapsule loading hydrocortisone sodium succinate. Drug Development and Industrial Pharmacy. 2016, 15: 448-457.
26. Dong K, Zeng AG, Wang ML, Dong YL, Wang K, Guo CN, Yan Y, Zhang L, Shi XP, Xing JF. In vitro and in vivo study of a colon-targeted resin microcapsule loading a novel prodrug, 3, 4, 5-tributyryl shikimic acid. RSC Advances. 2016, 6: 16882-16890.
27. Dong K, Dong YL, You CY, Xu W, Huang XY, Zhang L, Wang K, Xing JF. Assessment of the drug loading, in vitro and in vivo release behavior of novel pH-sensitive hydrogel. Drug Delivery. 2016, 23(1): 174-184.
28. Jing Jiajia, Wu Xianglong, Lu Tingli. Research progress in collagen tripeptides and their biological applications. life sciences. 2016, 28(9): 1-7.
29. Xi Duo, Lu Tingli. Advances in the study of macrophage origin and self-renewal. Modern immunology. 2016, 36(5): 415-419.
30. Qiang Chen, Wei Li, Ourania-Menti Goudouri, Yaping Ding, Sandra Cabanas-Polo, and Aldo R. Boccaccini. Electrophoretic deposition of antibiotic loaded PHBV microsphere-alginate composite coating with controlled delivery potential.Colloids and Surfaces B: Biointerfaces130 (2015) 199-206.
31. Qiang Chen, Sandra Cabanas-Polo, Yaping Ding, Aldo. R. Boccaccini, Bioactive glass-biopolymer multilayer coatings fabricated by electrophoretic deposition combined with layer-by-layer assembly. Key Engineering Materials, 654 (2015): 170-175.
32. Ning Cui, Junmin Qian, Ting Liu, Na Zhao, Hongjie Wang, Hyaluronic Acid Hydrogel Scaffolds with a Triple Degradation Behavior for Bone Tissue Engineering, Carbohydrate Polymers,2015,126:192-198.
33. Wen Zhao, Wenlong Liu, Jiaojiao Li, Xiao Lin, Ying Wang. Preparation of animal polysaccharides nanofibers by electrospinning and their potential biomedical applications.Journal of Biomedical Materials Research: Part A, 2015, 103: 807-818.
34. Zhang Yanni#, Han Yong*, Zhang Lan, Interfacial structure of the firmly adhered TiO2 nanotube films to titanium fabricated by a modified anodization, Thin Solid Films, 2015, 583: 151-157.
35. Zhang Yanni#, Han Yong*, Zhang Lan, Characterization of Zn-Doped TiO2 Nanotubes Anodized on Titanium Surface, Rare Metal Materials and Engineering, 2014, 4: 68-71.
36. Ning Cui, Junmin Qian, Na Zhao, Hongjie Wang, Functional Hyaluronic Acid Hydrogels Prepared by a Novel Method, Materials Science and Engineering: C,2014,45:573-577.
37. Qiang Chen, Liu Yufang, Yao Qingqing, Yu Shanshan, Zheng Kai, Pischetsrieder, Monika, A. R. Boccaccini. Multilayered bioactive composite coatings with drug delivery capability by electrophoretic deposition combined with layer-by-layer deposition.Advanced Biomaterials and Devices in Medicine1 (2014) 18-27.
38. Qiang Chen, Uxua Pérez de Larraya, Nere Garmendia, María Lasheras-Zubiate, Luis Cordero-Arias, Sannakaisa Virtanen, Aldo R. Boccaccini. Electrophoretic deposition of cellulose nanocrystals (CNs) and CNs/alginate nanocomposite coatings and free standing membranes.Colloids and Surfaces B: Biointerfaces,118 (2014): 41-48.
39. Qiang Chen, Sandra Cabanas-Polo, Ourania-Menti Goudouri, Aldo R. Boccaccini. Electrophoretic co-deposition of polyvinyl alcohol (PVA) reinforced alginate–Bioglass® composite coating on stainless steel: Mechanical properties and in-vitro bioactivity assessment.Materials Science and Engineering: C, 40 (2014): 55-64.
40. Tingli Lu, Ting Chen, Yuankun Zhai, Yufan Ma, Yuehong Xiao. Designer Functionalized Self-Assembling Peptide Scaffolds for Adhesion, Proliferation, and Differentiation of MC3T3-E1.Soft Materials. 12, 79-87, 2014.
41. X. L. Wu, W.T. Fan, Y. L. Pan, et al. Synthesis, crystal structure and anti-fatigue effects of some benzamide derivatives.Molecules. 2014, 19: 1034-1046.
42. X. L. Wu, W.T. Fan, Y. L. Pan, et al. Synthesis, spectroscopic properties, and biological applications of eight novel chlorinated fluorescent proteins-labeling probes.Journal of Fluorescence. 2014, 24(3):775-786.
43. Dong K, Dong YL, You CY, Xu W, Huang XY, Yan Y, Zhang L, Wang K, Xing JF. Assessment of the safety, targeting, and distribution characteristics of a novel pH-sensitive hydrogel.Colloid and Surface B-Biointerfaces. 2014, 123: 965-973.
44. Tingli Lu, Yuhui Li, Tao Chen. Techniques of Fabrication and Construction Three-dimensional Scaffolds for Tissue Engineering.International Journal of Nanomedicine. 8: 337–350, 2013.
45. Tingli Lu,Yuhui Li, Yunqing Wang, et al. Preparation and characterization of porous nano-sized hydroxyapatite/collagen composite as bone scaffold.Advanced Materials Research. 647: 62-66, 2013.
46. Wen Zhao, Hong Zhang, TingLi Lu, Wenlong Liu. Electrostatic self-assembly: an innovative approach to fabricate novel-structured magnetic liposomes.Applied Surface Science, 2013, 265: 101-107.
47. Wen Zhao, Wenlong Liu. Compatibility between Paclitaxel and Polymer Carrier.Applied Mechanics and Materials. 2013,420: 263-268.
48. Dong K, Xu W, You CY, Xing JF, Zhang JY, Gao Y, Wang K. Novel Biodegradable pH/Thermosensitive Hydrogels: Part 1. Preparation and Characterization.International Journal of Polymeric Materials and Polymeric Biomaterials.2013, 62(14): 726-732.
49. Chen Ting, Lu Tingli, Ma Yufan, Wang Yunqing, Xue Yuehong, Li Yuhui. Preliminary study on osteogenic differentiation of pre-osteoblast MC3T3-E1 in three-dimensional peptide scaffold. Materials Review, 2013, 27(2): 48 -51.
50. Qiang Chen, Luis Cordero-Arias, Judith A. Roether, Sandra Cabanas-Polo, Sannakaisa Virtanen, Aldo R. Boccaccini. Alginate/Bioglass® composite coatings on stainless steel deposited by direct current and alternating current electrophoretic deposition. Surface and Coatings Technology, 233 (2013): 49-56.
51. Tingli Lu, Zhao Wang, Yufan Ma, Yang Zhang, Tao Chen. Influence of polymer size, liposome composition, surface charge and temperature on the permeability of pH-sensitive liposomes containing lipid-anchored poly(2-ethylacrylic acid).International Journal of Nanomedicine. 7: 4917–4926.2012
52. Wang Yunqing, Lu Tingli, Chen Ting, Ma Yufan, Zhao Wen, Chen Tao. Research progress of self-assembled peptide scaffolds. Journal of Materials Science and Engineering. 2012, 311 (02): 324-328.
53. Kong Danfeng, Zhao Wen, Zhang Junping, Lu Tingli, Chen Tao. Computer simulation of optimal design of block copolymer micelle structure, Journal of Materials Science and Engineering, 2012, 30(2): 1-5.
54. Chen Tao, Wang Yitao, Hu Huijing, Fu Jingguo, Lu Tingli. Advances in the mechanism of propofol preparations causing pain at the injection site, International Journal of Anesthesiology and Resuscitation. 2012, 32(1): 109-112.
55. Hu Huijing, Chen Tao, Wang Yitao, Lu Tingli. Research progress in propofol injection pain and its preventive measures, Medical Herald. 2012, 31(1): 63-66.
56. Tingli Lu, Weiguang Sun, Wen Zhao, Tao Chen. Preparation of amifostine polylactide–co-glycolide microspheres and its irradiation protection in mouse through oral administration. Drug Development and Industrial Pharmacy. 37(12): 1473-1480, 2011.
57. Tingli Lu, Yufan Ma, Huijing Hu, Yun Chen, Wen Zhao, Tao Chen. Ethinylestradiol liposome preparation and its effects on ovariectomized rats’ osteoporosis, Drug Delivery. 18(7): 468-477, 2011.
58. Tingli Lu, Huijing Hu, Wen Zhao, Tao Chen. Synthesis and in vivo bioactivity of lipophilic alendronate derivatives against osteoporosis. Drug Development and Industrial Pharmacy. 2011, 37(6): 656-663.
59. X Wu, X Jin, Y Wang, Q Mei, J Li, Z Shi, Synthesis and spectral properties of novel chlorinated pH fluorescent probes. Journal of Luminescence. 2011, 131(4): 776-780.
60. Ma Yufan, Lu Tingli, Wang Yunqing, Zhao Wen, Mei Qibing, Chen Tao. Induction of hydrogen artemisinin on apoptosis of human osteosarcoma MG-63 cells. Chinese Journal of Cell Biology. 2011, (12 ): 1324-1330.
61. Chen Ting, Lu Tingli, Wang Yunqing, School Moon Red, Li Yuhui. Self-assembly of peptides and their applications in biomedicine, Materials Review. 2011, (19): 90-95.
62. Wang Yunqing, Lu Tingli, Zhao Wen, Hui Qianqian, Kong Danfeng, Chen Tao. Research progress of bone tissue engineering scaffold materials. Materials Review, 2011, (03): 125-131.
63. Lu Tingli, Zhang Hong, Wang Yunqing, Hui Qianqian, Zhao Wen. Research progress in biofunctionalization of tissue engineering scaffold materials, Journal of Materials Science and Engineering, 2011, (02): 301-307.
64. Zhang Zhigang, Lu Tingli, Hui Qianqian, Zhao Wen, Gao Jianli, Chen Tao. Design, Synthesis and Analysis of Dehydrocholinyl Derivatives of Bisphosphonates, Chinese Journal of Hospital Pharmacy. 2011,31(9): 5 -8.
65. Kong Danfeng, Zhao Wen, Lu Tingli, Hui Qianqian, Wang Yunqing, Chen Tao. Research progress of molecular imprinting technology in drug separation, Journal of Pharmaceutical Practice. 2011, 29(3): 161-164.
66. Li Yuhui, Lu Tingli. Research progress in tissue engineering scaffold materials, China Materials Science and Technology. 2011, 7(5): 15-18.
67. Zhang Xujun, Lu Tingli, Chen Tao, Gao Yingchun, Zhao Wen. Progress in Surface Modification of Injected Drug Microspheres, China Pharmaceutical Industry. 2011, 20(15): 1-3.
68. Lu Ting Li, Hu Hui Jing, Zhao Wen, Chen Tao. RP-HPLC analysis of hydrophobic alendronate amidated derivatives. Journal of Liquid Chromatography & Related Technologies, 2010,33(3): 349-361
69. Tingli Lu, Cui Fuxing. Synthesis and Properties of Non-functional Cubic Silsesquioxane Macromonomers. Designed Monomers and Polymers, 2010, 13(1): 73-85.
Patents
1. Rapidly degradable tough hydrogel wound dressing and preparation method thereof. Chinese invention patent, 201811606618.7
2. Multifunctional hydrogel adhesive suitable for dynamic tissue surface high strength bonding and preparation method thereof. Chinese invention patent, 201811541713.3
3. Functionalized mesoporous silica, and preparation thereof and application method in wound repair, Chinese invention patent, CN201810602708.2
4. Nano-plate assembled flower-shaped titanium phosphate microsphere and preparation method thereof, Chinese invention patent, CN201810143744.7
5. A *** freeze-dried powder and preparation method. National defense invention patent. Authorization number: ZL 201318006417.5, authorization date: 2016.9.7
6. A *** freeze-dried powder and preparation method. National defense invention patent. ZL 201318006417.5
7. Preparation and use of *** pharmacologically active compounds. National defense invention patent. ZL201318006415.6
8. Monomethoxy polyethylene glycol-poly L-tryptophan amphiphilic block copolymer, preparation method thereof and preparation method of drug-loaded micelle solution thereof. Chinese invention patent, ZL 201110132965.2
9. Benzoylamide compound and its preparation method. Chinese invention patent, ZL201110148165.X
10. Artemether/benzol compound fat emulsion intravenous injection and preparation method thereof. Chinese invention patent, ZL201010216610.7
11. Preparation method of bisphosphonate derivatives. Chinese invention patent, ZL 2006 1 0105179.2
12. Epimedium extract fat emulsion composition and preparation method thereof. Chinese invention patent, ZL 2006 1 0105343.X.
13. Preparation of estrogen liposomes. Chinese invention patent, ZL 2007 1 0017233.2
14. Magnetic liposome and preparation method thereof. Chinese invention patent, ZL200910022717
15. Mefloquine fat emulsion composition and preparation method thereof. Chinese invention patent, ZL 200910020907
